Differential cell adhesion molecule expression and lymphocyte mobilisation during prolonged aerobic exercise

摘要: This study was undertaken to determine the cell adhesion molecule profile of CD4+, CD8hi and CD56+ lymphocytes, which are mobilised from peripheral blood during after prolonged aerobic exercise. Ten healthy males (21–35 years old) were tested on two occasions, separated by at least 14 days. On first occasion, subjects examined in a rested state but did not second same time day before, 2 h exercise 65% peak oxygen consumption. Blood samples obtained rest (t 0), (at 0.5, 1, 1.5 2 h, t 2, respectively) 4 24 h, 24, analysed two-colour flow cytometry for surface expression, density CD62L, CD49d CD11a. At circulating concentrations CD56+, CD4+ lymphocytes had increased (P<0.05) 330%, 105% 30%, respectively. The majority 2 CD62L– CD11ahi, although populations cells that expressed CD62L+ CD11alo also mobilised. Changes subset 0.5 positively associated (r=0.63; P<0.01) with their corresponding mean CD11a 0. Our findings suggest differential mobilisation is linked expression (i.e. lymphocyte-function-associated antigen-1). However, mechanisms unrelated appear be involved.