Immunologic and clinical status of blood donors with subnormal levels of IgG2
作者： Moon H. Nahm , Kimberly Macke , Oh-Hun Kwon , Joseph V. Madassery , Laurence A. Sherman
DOI: 10.1016/0091-6749(90)90197-C
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摘要: Abstract To determine the immunologic and clinical status of individuals from a general population with subnormal levels IgG2, we prospectively studied 37 312 blood donors low IgG2 identified among 8015 donors. We examined (1) G2m(23) allotypes, (2) other IgG subclasses immunoglobulin classes, (3) composition peripheral leukocyte populations, (4) responses to two carbohydrate antigen vaccines, (5) in vitro secretion by isolated lymphocytes after mitogen stimulation, (6) histories. found that most (90%) had − whereas only 30% unselected . When were separated according their allotype, "normal" range for allotype is 35% lower than + allotype. Individuals who ≥0.8 but
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