Exploring Small Extracellular Vesicles for Precision Medicine in Prostate Cancer.

摘要: Tumor microenvironment constitutes a complex network in which tumor cells communicate among them and with stromal immune cells. It has been shown that cancer are able to exchange genetic materials through small extracellular vesicles (EVs), heterogeneous group of different size shape, cargo content, function. The importance investigate populations circulating EVs would be great as prostate (PCa) biomarkers. In several neoplasms well PCa, nanometer-sized endosomal origin implicated supporting growth metastatic spread by both altering local stroma creating protumor environment favors the formation pre-metastatic niches. Several techniques applicable for isolation analysis PCa-derived illustrated this article. Due high sensitivity specificity these techniques, have become ideal candidates early diagnosis. Moreover, we discuss role during PCa carcinogenesis, modulating development drug resistance hormonal therapy chemotherapy, thus underlining potential EV-tailored strategies patients.