Age-dependent elevations in plasma kisspeptin are observed in boys and girls when compared with adults

摘要: Background: Kisspeptin is a hypothalamic neuropeptide playing physiological role in human reproduction. Genetic over-activation of kisspeptin causes precocious puberty children. Concentrations circulating are low adults. The concentrations plasma boys and girls have not been studied previously. Methods: Blood was obtained from 51 children 63 Plasma samples were analysed using radioimmunoassay. Children aged 2–18 years, attending hospital for medically requested blood test unrelated to reproductive development. Data on pubertal status collected due ethical reasons. Results: Mean significantly higher when compared with adults (mean pmol/L: 12.3 � 0.9, adults; 40.9 3.3, children, P <0.001vs. adults). Overall mean different between sexes 39.5 3.2, boys; 44.3 6.3, girls, ¼0.48). In both sexes, increased age peak 9 12 years age, before decreasing beyond adulthood. highly elevated 9–12 59.5 18.3, <0.01vs. adult women; 43.8 6.2, boys, men). Conclusions: We report that Furthermore may distinct, age-dependent kisspeptin. Further studies determine if could be used as clinically useful biochemical marker development