ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.
作者： Ru-Rong Ji , Katia Befort , Gary J. Brenner , Clifford J. Woolf
DOI: 10.1523/JNEUROSCI.22-02-00478.2002
关键词:
摘要: Activation of ERK (extracellular signal-regulated kinase) MAP (mitogen-activated protein) kinase in dorsal horn neurons the spinal cord by peripheral noxious stimulation contributes to short-term pain hypersensitivity. We investigated activation inflammation and its involvement regulating gene expression contributing inflammatory Injection complete Freund's adjuvant (CFA) into a hindpaw produced persistent sustained superficial layers (laminae I-IIo) horn. CFA also induced an upregulation prodynorphin neurokinin-1 (NK-1) neurons, which was suppressed intrathecal delivery MEK (MAP inhibitor U0126. CFA-induced phospho-ERK primarily colocalized with NK-1 neurons. Although injection U0126 did not affect basal sensitivity, it attenuate both establishment maintenance heat mechanical pathway subset nociceptive contributes, therefore, hypersensitivity, possibly via transcriptional regulation genes, such as NK-1.
sci-hub.se 参考文章(63)
Ru-Rong Ji, Hiroshi Baba, Gary J. Brenner, Clifford J. Woolf, Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nature Neuroscience. ,vol. 2, pp. 1114- 1119 ,(1999) , 10.1038/16040
Matthew R. Lewin, Edgar T. Walters, Cyclic GMP pathway is critical for inducing long–term sensitization of nociceptive sensory neurons Nature Neuroscience. ,vol. 2, pp. 18- 23 ,(1999) , 10.1038/4520
A D Hershey, P E Dykema, J E Krause, Organization, structure, and expression of the gene encoding the rat substance P receptor. Journal of Biological Chemistry. ,vol. 266, pp. 4366- 4374 ,(1991) , 10.1016/S0021-9258(20)64331-9
Zhengui Xia, Henryk Dudek, Cindy K. Miranti, Michael E. Greenberg, Calcium Influx via the NMDA Receptor Induces Immediate Early Gene Transcription by a MAP Kinase/ERK-Dependent Mechanism The Journal of Neuroscience. ,vol. 16, pp. 5425- 5436 ,(1996) , 10.1523/JNEUROSCI.16-17-05425.1996
Tarek A. Samad, Kimberly A. Moore, Adam Sapirstein, Sara Billet, Andrew Allchorne, Stephen Poole, Joseph V. Bonventre, Clifford J. Woolf, Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity Nature. ,vol. 410, pp. 471- 475 ,(2001) , 10.1038/35068566
Carmen De Felipe, Juan F. Herrero, John A. O'Brien, James A. Palmer, Christopher A. Doyle, Andrew J. H. Smith, Jennifer M. A. Laird, Carlos Belmonte, Fernando Cervero, Stephen P. Hunt, Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. Nature. ,vol. 392, pp. 394- 397 ,(1998) , 10.1038/32904
Véronique Sgambato, Christiane Pagès, Monique Rogard, Marie-Jo Besson, Jocelyne Caboche, Extracellular Signal-Regulated Kinase (ERK) Controls Immediate Early Gene Induction on Corticostriatal Stimulation The Journal of Neuroscience. ,vol. 18, pp. 8814- 8825 ,(1998) , 10.1523/JNEUROSCI.18-21-08814.1998
Catherine Abbadie, Jodie Trafton, Hantao Liu, Patrick W. Mantyh, Allan I. Basbaum, Inflammation Increases the Distribution of Dorsal Horn Neurons That Internalize the Neurokinin-1 Receptor in Response to Noxious and Non-Noxious Stimulation The Journal of Neuroscience. ,vol. 17, pp. 8049- 8060 ,(1997) , 10.1523/JNEUROSCI.17-20-08049.1997
KE McCarson, JE Krause, NK-1 and NK-3 type tachykinin receptor mRNA expression in the rat spinal cord dorsal horn is increased during adjuvant or formalin- induced nociception The Journal of Neuroscience. ,vol. 14, pp. 712- 720 ,(1994) , 10.1523/JNEUROSCI.14-02-00712.1994
CJ Woolf, PD Wall, Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat The Journal of Neuroscience. ,vol. 6, pp. 1433- 1442 ,(1986) , 10.1523/JNEUROSCI.06-05-01433.1986