Mechanism of deoxycholic acid stimulation of the rabbit colon.
作者： S J Shiff , R D Soloway , W J Snape
DOI: 10.1172/JCI110538
关键词:
摘要: Previous studies showed that deoxycholic acid (DCA) stimulated migrating action potential complexes (MAPC) in the colon. The aim of this study was to clarify mechanism DCA-stimulated colonic motility. Myoelectrical and contractile activity were measured New Zealand White rabbits from a loop constructed proximal During control period, slow waves present at frequency 10.8 +/- 0.5 cycle/min there 1.5 MAPC/ h. After adding DCA (16 mM) wave unchanged. However, MAPC increased 15.1 2.4 MAPC/h (P less than 0.001). not smooth muscle outside loop. intraluminal addition procaine or tetrodotoxin inhibited increase (0.2 0.2 MAPC/h) 0.005). Intravenous administration atropine phentolamine also had been by Pretreatment with 6-hydroxydopamine an activity. Propranolol, trimethaphan camsylate, hexamethonium no effect on stimulation Although concentration bile salt mesenteric venous outflow loop, intravenous did stimulate These suggest: (a) is local phenomenon, (b) dependent intact cholinergic alpha adrenergic neurons, (c) salts serum associated
sci-hub.st 参考文章(15)
W. J. Snape, S. Shiff, S. Cohen, Effect of deoxycholic acid on colonic motility in the rabbit. American Journal of Physiology. ,vol. 238, ,(1980) , 10.1152/AJPGI.1980.238.4.G321
Henry J. Binder, Charles Filburn, Bruce T. Volpe, Bile salt alteration of colonic electrolyte transport: role of cyclic adenosine monophosphate. Gastroenterology. ,vol. 68, pp. 503- 508 ,(1975) , 10.1016/S0016-5085(75)80089-8
Gerald M. Carlson, Sidney Cohen, Effect of Salmonella typhimurium on myoelectrical activity in the rabbit ileum Gastroenterology. ,vol. 74, pp. 47- 51 ,(1978) , 10.1016/0016-5085(78)90354-2
G. M. Lees, H. W. Kosterlitz, PHARMACOLOGICAL ANALYSIS OF INTRINSIC INTESTINAL REFLEXES. Pharmacological Reviews. ,vol. 16, pp. 301- 339 ,(1964)
Osuga Toshiaki, Mitamura Keiji, Mashige Fumiko, Imai Kazuhiro, Evaluation of fluorimetrically estimated serum bile acid in liver disease Clinica Chimica Acta. ,vol. 75, pp. 81- 90 ,(1977) , 10.1016/0009-8981(77)90502-2
M. Flynn, C. Darby, J. Hyland, P. Hammond, I. Taylor, The effect of bile acids on colonic myoelectrical activity British Journal of Surgery. ,vol. 66, pp. 776- 779 ,(2005) , 10.1002/BJS.1800661106
Dean R. Conley, Martin J. Coyne, George G. Bonorris, Ane Chung, Leslie J. Schoenfield, Bile acid stimulation of colonic adenylate cyclase and secretion in the rabbit The American Journal of Digestive Diseases. ,vol. 21, pp. 453- 458 ,(1976) , 10.1007/BF01072128
GEOFFREY W. G. SHARP, SIXTUS HYNIE, Stimulation of intestinal adenyl cyclase by cholera toxin. Nature. ,vol. 229, pp. 266- 269 ,(1971) , 10.1038/229266A0
W O Kirwan, A N Smith, W D Mitchell, J D Falconer, M A Eastwood, Bile acids and colonic motility in the rabbit and the human. Gut. ,vol. 16, pp. 894- 902 ,(1975) , 10.1136/GUT.16.11.894
Daniel V. Kimberg, Michael Field, Judith Johnson, Antonia Henderson, Elaine Gershon, Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins Journal of Clinical Investigation. ,vol. 50, pp. 1218- 1230 ,(1971) , 10.1172/JCI106599