Hydration and elevated calcium alone do not produce xylose nuclear cataract: role of proteolysis by calpain.

摘要: The purpose of this experiment was to determine the contribution calpain proteolytic enzyme (EC 3.4.22.17) in formation nuclear cataract during lens culture xylose. Increased calcium found be required for xylose our system. Inhibition by cysteine protease inhibitor E64 effective slowing cataract, even though and hydration were markedly elevated. These results showed that elevated alone do not produce they indicated proteolysis may necessary rat lens.