Involvement of calpain in diamide-induced cataract in cultured lenses.
作者： Mitsuyoshi Azuma , Thomas R. Shearer
DOI: 10.1016/0014-5793(92)80703-J
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摘要: Abstract Lenses cultured in diamide first developed outer cortical opacities followed by nuclear cataract. Lens hydration and total calcium were markedly increased diamide. Proteolysis or crystallins observed cataract lenses. Calpain the soluble fraction of lenses with was decreased, while calpain insoluble increased. Co-culture E64d, an inhibitor cysteine protease such as calpain, especially prevented proteolysis crystallins, indicating that involved formation
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