Risks of congenital malformations in offspring exposed to valproic acid in utero: A systematic review and cumulative meta‐analysis

摘要: Despite extensive research efforts over decades, the teratogenic profile of valproic acid (VPA) remains obscure. We performed cumulative and conventional meta-analyses cohort studies to determine time profiles signal emergence VPA-associated congenital malformations (CMs) define risk estimates each CMs. Fifty-nine were identified analyzed. found that significant signals began emerge last 10-20 years even before large-scale performed: neural tube defect (the emerged in 1992); genitourinary musculoskeletal anomalies (2004); cleft lip and/or palate (2005); heart defects (2006). At present, risks CMs are 2-7-fold higher than other common antiepileptic drugs. VPA should not be used as a first-line therapy women childbearing age unless it is only option for patient.