Cardiac malformations are increased in infants of mothers with epilepsy.

摘要: We aimed to ascertain the prevalence of cardiac malformation (CM) and its association with antenatal exposure an antiepileptic drug (AED) in infants mothers epilepsy (IMEs). Women (WWE) are enrolled Kerala Registry Epilepsy Pregnancy (KREP) prepregnancy or early pregnancy period followed up a standard protocol until IMEs 6 years old. At 3 months postpartum, cardiologist, blinded AED exposure, carried out clinical examination echocardiography on all live-born babies. Patent foramen ovale (PFO) interatrial septal defects < 5 mm size were excluded from CM. Details maternal epilepsy, folate usage, first trimester, newborn characteristics abstracted records KREP. examined 462 Maternal was generalized 201 (43.50%) localization related 241 (52.2%). The monotherapy 262 (56.7%)—carbamazepine (112), valproate (71), phenobarbitone (43), phenytoin (31), clonazepam (2)—and polytherapy 126 (27.3%). Seventy-four (16.01%) had no exposure. There 36 CM (7.8%; 95% confidence interval: 5.5–10.6). CMs included atrial defect (26; 72.2%), tetrology Fallot (3; 8.3%), patent ductus arteriosus pulmonic stenosis (2 each; 5.6%), ventricular defect, tricuspid regurgitation, transposition great arteries (1 2.8%). significantly more for premature birth (p .003). between age, syndrome, seizure frequency during pregnancy, use. frequent (13; 10.3%) compared (17; 6.5%). Those trend (not statistically significant) toward higher other AEDs as monotherapy.