Pregnancy in women with epilepsy : preliminary results of Kerala registry of epilepsy and pregnancy.

摘要: Eighty-five women with epilepsy were followed up for reproductive functions under the registry of and pregnancy. 32 them had completed Their mean age was 26 years seizure frequency 0.7 during current Nineteen (59.4%) generalized epilepsy. Nine not on any anti epileptic drugs (AED), 23 various AEDs, 19 being monotherapy. Only 40% taking folic acid Pregnancy ended as spontaneous abortion in one patient. Nearly third required cesarean section. Majority (87.5%) term babies. Three (10.7%) babies birth asphyxia. Six (21.4%) low weight. Congenital malformations detected four cases (12.5%). Malformations included neural tube defects, talipes equinovarus other minor anomalies. These exposed to sodium valproate, carbamazepine or phenobarbitone. The risk malformation significantly greater (p<0.05) when mother odds ratio much higher valproate (6) than that (1.2) phenobarbitone (0.8). safe pregnancy childbirth without aggravation