Genetic liability to epilepsy in Kerala State, India.

摘要: Abstract Background: Familial clustering is common in epilepsies, but pedigree patterns suggest a multi-factorial inheritance. Genetic liability for inheritance population specific and such data are not available the of Kerala or other states south India. Objectives: In this study, we have attempted to determine genetic epilepsy based on an adult state. Material methods: Pedigrees were recorded probands who reported Registry Epilepsy Pregnancy. order obtain genetically matched sample comparison estimation empiric risks, used family history spouse except when was proband's relative. The ILAE criteria followed diagnosis classification epilepsy. Results: Data collected 18,419 members 505 with (82 men 423 women) 10,231 spouses (control). frequency first second-degree relatives comparable (0.5%), justifying use as control. Positive observed 22.2% 8.24% controls (Odd's Ratio 3.2, 95% Confidence Interval 2.12–4.73). An affected first-degree relative 7.5% probands. corresponding figure GE, LRE epileptic syndromes 10.2%, 5.8% 5.12%, respectively. segregation ratio Juvenile Myoclonic (JME) (1:19) higher than that types Generalized (GE) (1:24) Localization Related (LRE) (1:52). Prevalence among (1.96%) greater square root (0.51%) (1.24%) third-degree (0.64%) Probands had parental consanguinity (13.07%) compared (6.64%). above factors support complex (heritability) GE (0.6) significantly JME (0.7) (0.4). A limitation study inferences predominantly female proband no gender differences identified. Conclusions: observations indicate values useful counseling local population. Further studies involving more individuals from younger age group male envisaged.