The impact of quasispecies dynamics on the use of therapeutics

摘要: The application of quasispecies theory to viral populations has boosted our understanding how endogenous and exogenous features condition their adaptation. Mounting empirical evidence demonstrates that internal interactions within mutant spectra may cause unexpected responses antiviral treatments. In this scenario, increased mutagenesis could be efficient at low mutagen doses due the lethal action defective genomes, whereas sequential administration drugs might superior combination therapies. Our ability predict outcome a particular therapy takes advantage complementary use in vivo observations, vitro experiments, mathematical models.