A Retinoic Acid Receptor-Specific Element Controls the Retinoic Acid Receptor-β Promoter
作者： Birgit Hoffmann , Jürgen M. Lehmann , Xiao-kun Zhang , Thomas Hermann , Matthias Husmann
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摘要: The morphogen retinoic acid (RA) regulates gene transcription by interacting with specific nuclear receptors that recognize DNA sequences near responsive promoters. While much has recently been learned about the receptor proteins, little is known genes are directly regulated RA and their cis-acting response elements recognized these receptors. Here we have analyzed receptor-β (RARβ) promoter controlled RA. We find a RA-responsive element (RARE) located adjacent to TATA box. RARE shows direct repeat symmetry which essential for its function. thyroid hormone-responsive can also function as RAR elements, show here this activated endogenous RARs RARβ, but cannot be hormone other In addition, RARγ poor activator of RARE. However, bound high affinity both RARβ well ...
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