Short-term effects of overnight orthokeratology on corneal epithelial permeability and biomechanical properties.

摘要: Author(s): Yeh, Thao N; Green, Harry M; Zhou, Yixiu; Pitts, Julie; Kitamata-Wong, Britney; Lee, Sophia; Wang, Shiyin L; Lin, Meng C | Abstract: To investigate the effects of 30 nights overnight orthokeratology (OOK) on corneal epithelial permeability (Pdc) and biomechanical properties.BE Retainer Paragon CRT lenses were used. Visits scheduled approximately 4 hours after awakening at baseline 1, 5, 10, 14, days treatment. Pdc was measured day 30, whereas properties visual acuities (VAs) all visits.Thirty-nine neophytes soft contact lens wearers completed study. There no difference in between (ln[Pdc] [95% confidence interval (CI)] = -2.65 [-2.80 to -2.50]) (ln[Pdc][CI] -2.68 [-2.85 (P 0.88). Corneal hysteresis (CH) resistance factor (CRF) reduced significantly from (CH [CI] 10.89 [10.59-11.19] mm Hg CRF 10.35 [9.99-10.72] Hg) 10.59 [10.31-10.87] 9.58 [9.26-9.89] 0.001 for CH P l CRF). Posttreatment VA did not reach targets, worse with low-contrast letters. Asian individuals (n 18) had than non-Asian 21) under most conditions through extended 14 letters mesopic conditions. The percentage participants who achieved 20/20 uncorrected 17% 40% 1 reached 69% 83% 30.Thirty OOK alter when awakening. caused decrease, but changes clinically significant compared diseased postsurgical cases. individuals, lower this study, responded slower based early overrefraction measurements.