Post-natal incidence of HIV-I infection among children in a rural Ugandan population: no evidence for transmission other than mother to child.

摘要: We conducted a prospective cohort study to determine the post-natal incidence of and possible transmission routes for HIV-I infection in rural Ugandan children. The consisted population cluster 15 villages Masaka District, south-west Uganda, was enrolled 1989-1990 through demographic serological survey. During period 1991-1993 resurveyed annually. A total 5492 children aged 0-12 years were enrolled; these, 41 (0.7%) seropositive infants. 3941 (72%) HIV-negative on enrolment had at least one follow-up specimen. 8596 person-years observation only I seroconversion observed, an rate 0.12 (95% CI 0.00-0.35) per 1000 observation. HIV most probably breast milk. case corresponds 1.1 households with or more HIV-positive adults (874 observation); no incident observed seronegative (6423 observation). Thus, among this is virtually exclusively result mother-to-child transmission. No infections attributable parenteral exposure, non-sexual casual household contact, insects.