Innate-Like and Conventional T Cell Populations from Hemodialyzed and Kidney Transplanted Patients Are Equally Compromised
作者： Marine Baron , Renata Belo , Dominique Cathelin , Lucia Moreira-Teixeira , Claire Cartery
DOI: 10.1371/JOURNAL.PONE.0105422
关键词:
摘要: Clinicians are well aware of existing pharmacologically-induced immune deficient status in kidney-transplanted patients that will favor their susceptibility to bacterial or viral infections. Previous studies indicated advanced Stage 4–5 Chronic Kidney Disease might also be regarded as an deficiency-like well, even though the mechanisms not fully understood. Here, we analyzed ex vivo frequency and functional properties both conventional innate-like T (ILT) lymphocyte subsets peripheral blood 35 on hemodialysis, 29 kidney transplanted 38 healthy donors. We found cell count ILT cells, iNKT (invariant Natural Killer T) MAIT (mucosal-associated invariant T), were significantly decreased hemodialyzed compared controls. This deficiency was observed regarding including IL-17-producing CD4+ Th17 cells. Pertaining regulatory noticed major modifications global CD4+CD25+Foxp3+ lymphocytes, resting suppressive CD45RA+Foxp3lo activated CD45RA−Foxp3hi subpopulations. no significant differences between subjects. In conclusion, demonstrated numbers equally impaired patients.
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