Extrafollicular Dermal Melanocyte Stem Cells and Melanoma
作者： James D. Hoerter , Patrick Bradley , Alexandria Casillas , Danielle Chambers , Carli Denholm
DOI: 10.1155/2012/407079
关键词:
摘要: Recent studies suggest that extrafollicular dermal melanocyte stem cells (MSCs) persist after birth in the superficial nerve sheath of peripheral nerves and give rise to migratory precursors when replacements for epidermal melanocytes are needed on basal layer skin. If a damaged MSC or precursor can be shown primary origin melanoma, targeted identification eradication it by antibody-based therapies will best method treat melanoma very effective way prevent its recurrence. Transcription factors signaling pathways involved self-renewal, expansion differentiation reviewed. A model is presented show how detrimental effects long-term UVA/UVB radiation DNA repair mechanisms MSCs convert them cells. Zebrafish have many advantages investigating role development melanoma. The regulating zebrafish similar those found humans mice. ability easily manipulate population makes an excellent studying damage may lead
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