CDKN2A, CDKN2B and p14ARF are frequently and differentially methylated in ependymal tumours.

摘要: Ependymal tumours are histologically and clinically varied lesions. Numerical abnormalities of chromosome 9 frequently associated with these tumours. Nevertheless, the three important tumour suppressor genes located in this chromosome, CDKN2A, CDKN2B p14 ARF, have not been reported to be commonly altered them. We studied promoter methylation genes, an mechanism gene silencing a series 152 ependymal WHO grades I III. Methylation status ARF promoters was assessed by methylation-specific polymerase chain reaction genetic results were correlated clinicopathological features. observed for CDKN2A 21% (26/123) tumours, 32% (23/71) (23/108). For all posterior fossa ependymomas less methylated paediatric patients than adults. CDKN2B, extracranial more intracranial ones. frequent low-grade tumours; reverse CDKN2A. 21-32% Frequencies according This suggests role ependymoma tumorigenesis.