Distinct Secretory Activity and Clinical Impact of Subcutaneous Abdominal Adipose Tissue in Women with Rheumatoid Arthritis and Osteoarthritis.
作者： Ewa Kontny , Agnieszka Zielińska , Urszula Skalska , Krystyna Księżopolska-Orłowska , Piotr Głuszko
DOI: 10.1007/S10753-016-0459-3
关键词:
摘要: In the general population, low-grade inflammation of adipose tissue accompanies obesity and contributes to cardiovascular disease (CVD) development, but implication this in rheumatic pathology is unclear. Therefore, we characterized secretory activity subcutaneous abdominal (SAAT) females with rheumatoid arthritis (RA) osteoarthritis (OA) searched for its relationship intensity systemic inflammation, body composition comorbidity. The secretion classical adipokines (leptin, adiponectin), pro- anti-inflammatory factors, i.e. interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor (TNF), macrophage migration inhibitory (MIF) hepatocyte growth (HGF), from SAAT explants was measured by specific enzyme-linked immunosorbent assays. Patients’ evaluated bioelectric impendence technique. Rheumatoid secreted more adiponectin, IL-6, TNF MIF less leptin than respective tissues. RA patients, correlated cachectic composition, HGF release linked secondary amyloidosis visceral fat rating an independent risk CVD. OA, positively, while adiponectin inversely, markers, This study reveals differences between OA patients suggests different clinical impact these diseases, high- respectively. RA, may directly or via effect on contribute amyloidosis, cachexia CVD co-occurring, SAAT-derived adipocytokines rather regulate redound emergence.
springer.com
sci-hub.se 参考文章(42)
Frank C Arnett, None, Revised criteria for the classification of rheumatoid arthritis. Bulletin on The Rheumatic Diseases. ,vol. 38, pp. 1- 6 ,(1989)
Tadashi Nakamura, Amyloid A amyloidosis secondary to rheumatoid arthritis: pathophysiology and treatments. Clinical and Experimental Rheumatology. ,vol. 29, pp. 850- 857 ,(2011)
A Stofkova, Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity Endocrine Regulations. ,vol. 43, pp. 157- 168 ,(2009)
Takahiro Nakamura, Katsuya Sakai, Toshikazu Nakamura, Kunio Matsumoto, Hepatocyte growth factor twenty years on: Much more than a growth factor Journal of Gastroenterology and Hepatology. ,vol. 26, pp. 188- 202 ,(2011) , 10.1111/J.1440-1746.2010.06549.X
Ziba Farajzadegan, Hadi Karimzadeh, Maryam Mirpourian, Mansour Salesi, Hadi Abdolahi, The association of body mass index with disease activity and clinical response to combination therapy in patients with rheumatoid arthritis. Journal of Research in Medical Sciences. ,vol. 19, pp. 509- 514 ,(2014)
Florent Eymard, Audrey Pigenet, Danièle Citadelle, Charles-Henri Flouzat-Lachaniette, Alexandre Poignard, Chantal Benelli, Francis Berenbaum, Xavier Chevalier, Xavier Houard, Induction of an inflammatory and prodegradative phenotype in autologous fibroblast-like synoviocytes by the infrapatellar fat pad from patients with knee osteoarthritis. Arthritis & Rheumatism. ,vol. 66, pp. 2165- 2174 ,(2014) , 10.1002/ART.38657
Joshua F. Baker, Joan Von Feldt, Sogol Mostoufi-Moab, Ghaith Noaiseh, Elena Taratuta, Woojin Kim, Mary B. Leonard, Deficits in muscle mass, muscle density, and modified associations with fat in rheumatoid arthritis Arthritis Care and Research. ,vol. 66, pp. 1612- 1618 ,(2014) , 10.1002/ACR.22328
Iannis Adamopoulos, Nicholas Athanasou, Hepatocyte growth factor in normal and diseased bone and joint tissues. Current Rheumatology Reviews. ,vol. 2, pp. 1- 7 ,(2006) , 10.2174/1573397110602010001
Ayse Bag-Ozbek, Jon T. Giles, Inflammation, Adiposity, and Atherogenic Dyslipidemia in Rheumatoid Arthritis: Is There a Paradoxical Relationship? Current Allergy and Asthma Reports. ,vol. 15, pp. 497- ,(2015) , 10.1007/S11882-014-0497-6
Sandra Galic, Jon S. Oakhill, Gregory R. Steinberg, Adipose tissue as an endocrine organ. Molecular and Cellular Endocrinology. ,vol. 316, pp. 129- 139 ,(2010) , 10.1016/J.MCE.2009.08.018