Hepatocyte growth factor in normal and diseased bone and joint tissues.
作者： Iannis Adamopoulos , Nicholas Athanasou
DOI: 10.2174/1573397110602010001
关键词:
摘要: Hepatocyte Growth Factor (HGF) is a multifunctional growth factor which, like its receptor c-Met, widely expressed in osteoarticular tissues. HGF has profound effects on cell motility and differentiation tissue morphogenesis angiogenesis. plays an important role normal bone cartilage turnover. Changes HGF/c-Met have also been linked to pathophysiological changes several joint disorders. implicated the pathogenesis of inflammatory rheumatoid synovium degenerative osteoarthritis. influences remodelling significant proliferation osteoclast precursors, activity survival. A therapeutic proposed regeneration
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Øyvind Hjertner, Maria Lyngaas Torgersen, Carina Seidel, Henrik Hjorth-Hansen, Anders Waage, Magne Børset, Anders Sundan, Hepatocyte Growth Factor (HGF) Induces Interleukin-11 Secretion From Osteoblasts: A Possible Role for HGF in Myeloma-Associated Osteolytic Bone Disease Blood. ,vol. 94, pp. 3883- 3888 ,(1999) , 10.1182/BLOOD.V94.11.3883
W. M. Mars, G. K. Michalopoulos, R. Zarnegar, Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA. American Journal of Pathology. ,vol. 143, pp. 949- 958 ,(1993)
Dan P. Felsenfeld, Pamela L. Schwartzberg, Ana Venegas, Richard Tse, Michael P. Sheetz, Selective regulation of integrin--cytoskeleton interactions by the tyrosine kinase Src. Nature Cell Biology. ,vol. 1, pp. 200- 206 ,(1999) , 10.1038/12021
Kari Alitalo, Luca Tamagnone, Juha Partanen, Kinya Ohgami, Elina Armstrong, Tetsushi Tazunoki, Jerzy Lasota, Kay Huebner, Sal LaForgia, The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain. Oncogene. ,vol. 8, pp. 2009- 2014 ,(1993)
Peter J. Polverini, Katrin Lamszus, Liang Jin, Itzhak D. Goldberg, Ansamma Joseph, Eliot M. Rosen, Yan Yao, Alexander Fuchs, Soheli Chowdhury, Scatter factor binds to thrombospondin and other extracellular matrix components. American Journal of Pathology. ,vol. 149, pp. 805- 819 ,(1996)
M C DeFrances, R Zarnegar, Q Chen, Induction of met proto-oncogene (hepatocyte growth factor receptor) expression during human monocyte-macrophage differentiation Cell Growth & Differentiation. ,vol. 7, pp. 821- 832 ,(1996)
L. Naldini, L. Tamagnone, E. Vigna, M. Sachs, G. Hartmann, W. Birchmeier, Y. Daikuhara, H. Tsubouchi, F. Blasi, P.M. Comoglio, Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. The EMBO Journal. ,vol. 11, pp. 4825- 4833 ,(1992) , 10.1002/J.1460-2075.1992.TB05588.X
K. Miyazawa, T. Shimomura, A. Kitamura, J. Kondo, Y. Morimoto, N. Kitamura, Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII. Journal of Biological Chemistry. ,vol. 268, pp. 10024- 10028 ,(1993) , 10.1016/S0021-9258(18)82167-6
C. Boccaccio, G. Gaudino, G. Gambarotta, F. Galimi, P.M. Comoglio, Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF. Journal of Biological Chemistry. ,vol. 269, pp. 12846- 12851 ,(1994) , 10.1016/S0021-9258(18)99953-9
N.A. Lokker, P.J. Godowski, Generation and characterization of a competitive antagonist of human hepatocyte growth factor, HGF/NK1. Journal of Biological Chemistry. ,vol. 268, pp. 17145- 17150 ,(1993) , 10.1016/S0021-9258(19)85314-0