Administration of a selective il-6-trans-signalling inhibitor

作者: Ian Cottingham , Niclas Axel Petri

DOI:

关键词:

摘要: A selective IL-6- trans -signalling inhibitor can be used to treat a variety of mediated conditions, including inflammatory diseases and cancer. The safely administered humans at doses. Moreover, the lessens deleterious effects associated with other IL-6 inhibitors such as lowering neutrophil counts, platelet counts levels C-reactive protein.

参考文章(10)
Dirk Seegert, Georg H. Wätzig, Sgp130/Fc dimers ,(2015)
Dirk Seegert, Georg H Waetzig, Improved sgp130fc dimers ,(2007)
Stephanie Dr. Tenhumberg, Stefan Rose-John, Georg H. Wätzig, Jürgen Scheller, Joachim Grötzinger, Soluble gp130 muteins with improved binding activity ,(2008)
Stephanie Tenhumberg, Georg H. Waetzig, Athena Chalaris, Björn Rabe, Dirk Seegert, Jürgen Scheller, Stefan Rose-John, Joachim Grötzinger, Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130. Journal of Biological Chemistry. ,vol. 283, pp. 27200- 27207 ,(2008) , 10.1074/JBC.M803694200
Georg H Waetzig, Stefan Rose-John, Hitting a complex target: an update on interleukin-6 trans-signalling Expert Opinion on Therapeutic Targets. ,vol. 16, pp. 225- 236 ,(2012) , 10.1517/14728222.2012.660307
Jan Sommer, Christoph Garbers, Janina Wolf, Ahmad Trad, Jens M. Moll, Markus Sack, Rainer Fischer, Joachim Grötzinger, Georg H. Waetzig, Doreen M. Floss, Jürgen Scheller, Alternative intronic polyadenylation generates the interleukin-6 trans-signaling inhibitor sgp130-E10. Journal of Biological Chemistry. ,vol. 289, pp. 22140- 22150 ,(2014) , 10.1074/JBC.M114.560938
Kin-Ming Lo, Jeffrey C. Way, Yuan Liu, Stephen D. Gillies, Anti-il-6 antibodies preventing the binding of il-6 complexed with il-6ralpha to gp130 ,(2006)