Risk prediction for early-onset gastric carcinoma: a case-control study of polygenic gastric cancer in Han Chinese with hereditary background

摘要: // Jiajia Yuan 1 , Yanyan Li Tiantian Tian Na Yan Zhu Jianling Zou Jing Gao and Lin Shen Department of Gastrointestinal Oncology, Key laboratory Carcinogenesis Translational Research (Ministry Education/Beijing), Peking University Cancer Hospital Institute, Beijing, China Correspondence to: Shen, email: Gao, Keywords : gastric cancer; susceptibility; polymorphisms; risk classifications; Pathology Section Received December 28, 2015 Accepted March 31, 2016 Published April 26, Abstract Recent genomewide studies have identified several germline variations associated with cancer. The aim the present study was to identify, in a Chinese Han population, individual combined effects those single nucleotide polymorphisms (SNPs) that increase early-onset We conducted case-control comprising 116 patients cancer as well 102 sex- age-matched controls confirmed SNPs MUC1 (mucin 1) rs9841504 ZBTB20 (zinc finger BTB domain containing 20) rs4072037 were an increased risk. Of diagnosed cancer, 65 had at least direct lineal relative carcinoma digestive system or breast/ovarian These another 4 susceptibility: PSCA (prostate stem cell antigen) rs2294008, PLCE1 ( phospholipase C epsilon ) rs2274223, PTGER4 / PRKAA1 (prostaglandin E receptor 4/ protein kinase AMP-activated catalytic subunit alpha rs13361707, TYMS (thymidylate synthetase) rs2790. However, each these low-penetrance susceptibility alone is not considered influential enough predict absolute Thus we decided different combinations polygenes they affected for our population. Those subjects both alleles greater than 3-fold Also hereditary background including rs2274223 rs13361707 3 times more susceptible cardia without. findings show polymorphisms, instead susceptibility, may lead high-risk classification specific