Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase gene predict risk and survival in gastric cancer.

摘要: Thymidylate synthase (TYMS) plays a crucial role in folate metabolism as well DNA synthesis and repair. We hypothesized that functional polymorphisms the 3′ UTR of TYMS are associated with gastric cancer risk survival. In present study, we tested our hypothesis by genotyping three potentially (at miRNA binding sites) SNPs (rs16430 6bp del/ins, rs2790 A>G rs1059394 C>T) 379 patients 431 cancer-free controls. Compared rs16430 6bp/6bp + 6bp/0bp genotypes, 0bp/0bp genotype was significantly increased (adjusted OR = 1.72, 95% CI = 1.15–2.58). Similarly, GG TT genotypes were also OR = 2.52, CI = 1.25–5.10 adjusted OR = 1.57, CI = 1.04–2.35, respectively), compared AA + AG CC + CT respectively. haplotype analysis, T-G-0bp risk, C-A-6bp OR = 1.34, CI = 1.05–1.72). Survival analysis revealed poor survival who received chemotherapy treatment HR = 1.61, CI = 1.05–2.48 HR = 1.59, CI = 1.02–2.48, respectively). These results suggest these variants sites may be patients. Larger population studies warranted to verify findings. © 2014 Wiley Periodicals, Inc.