Folate metabolism genes, vegetable intake and renal cancer risk in central Europe.
作者： Lee E. Moore , Rayjean Hung , Sara Karami , Paolo Boffetta , Sonya Berndt
DOI: 10.1002/IJC.23318
关键词:
摘要: In a multicenter case-control study of renal cell carcinoma (RCC) conducted in central and eastern Europe, we reported strong inverse association with high vegetable intake RCC risk. The odds ratio (OR) for compared to the lowest tertile was OR = 0.67; (95% confidence interval (CI): 0.53-0.83; p-trend T (rs234706), Ex13 +41C > (rs1801181), Ex18 -391 G A (rs12613); MTHFR: A222V Ex5+79C (rs1801133), Ex8-62A C (rs1801131); MTR: Ex26 20A (rs1805087), MTRR: Ex5+136 (rs161870), TYMS:IVS2-405 (rs502396), Ex8+157 (rs699517), Ex8+227 (rs2790)) were analyzed among 1,097 cases 1,555 controls genotyped this study. Having at least 1 variant allele MTHFR associated higher risk those 2 common (CC) alleles (OR 1.44; 95% CI: 1.17-1.77; p 0.001). After stratification by intake, genotype only observed low medium tertiles (p-trend 0.001), but not highest (p-interaction 0.22). remained robust after calculation false discovery rate (FDR 0.05). Of 3 TYMS SNPs examined, IVS2 -405 (rs502396) significantly lower 0.73; 0.57-0.93). Vegetable modified between all < 0.04 all). summary, these findings suggest that variation genes may be risk, particularly when is low.
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