Entamoeba histolytica cell movement: A central role for self-generated chemokines and chemorepellents

摘要: Entamoeba histolytica cells, the cause of amoebic dysentery, are highly motile, and this motility is an essential feature pathogenesis morbidity amoebiasis. However, control E. within gut during invasion poorly understood. We have used improved chemotaxis assay to identify key extracellular signals mediating chemotaxis. The dominant responses we observe caused by factors generated cells themselves. Medium that has been conditioned growth causes both chemokinesis negative speed random movement more than doubled in compared with fresh medium, move efficiently away from medium Ethanol, product glucose metabolism, principal component chemokinetic response. closely related but nonpathogenic dispar shows no change response implying these central pathogenesis.