HLA alleles in renal transplant recipients with nonmelanoma skin cancer in southeastern Brazil.

摘要: BACKGROUND Renal transplant recipients are submitted to immunosuppression avoid graft rejection, which makes them susceptible various conditions. Furthermore, these individuals present malignant tumors more frequently than the general population, including nonmelanoma skin cancer. The individual genetic basis that acts in pathogenesis of cutaneous cancer may a protection or susceptibility factor for disease development. One factors is HLA complex. OBJECTIVE To investigate alleles association occurrence renal from Sao Paulo State. METHODS A total 213 patients (93 with and 120 without cancer) were evaluated by retrospective cross-sectional study. Epidemiological, clinical typing data found databases. class I (A, B) II (DR) compared establish their RESULTS Comparing cancer, HLA-B*13 allele was associated higher risk developing while B*45 B*50 protection. STUDY LIMITATIONS A, B DR identification kidney transplantation routine done low medium resolution techniques do not allow discrimination specific alleles. CONCLUSION involvement confirmed this showed (OR= 7.29) should be monitored long period time after transplantation.