Role of cytotoxic T cells in experimental myocarditis
作者： Nancy Van Houten , Sally Ann Huber
DOI: 10.1007/BF00197085
关键词:
摘要: Clearly, cytotoxic T lymphocytes play a pivotal role in the pathogenesis of CVB3 experimental myocarditis. The various types CTL generated indicate complex immune process. Virus-specific VCTL and metabolic antigen-specific MCTL are both contained CD4+ cell population, suggesting that presentation reactive epitopes context class II MHC, result less traditional virus particle recognition by CTL. ACTL, specific for on uninfected cells, CD8+ evidence indicates they directed to cellular receptor. Generation ACTL is primary pathogenic effector protection from damage mediated active suppression. mediation autoimmune response receptor remains an enigma. Elucidation this mechanism can provide insight into virus-induced disease.
springer.com
sci-hub.se 参考文章(28)
S. A. Huber, P. A. Lodge, L. P. Job, The Role of Virus-, and Immune-Mediated Cardiocyte Injury in Coxsackievirus B3-Induced Myocarditis Springer, Berlin, Heidelberg. pp. 64- 73 ,(1984) , 10.1007/978-3-642-95448-1_8
S. A. Huber, K. Simpson, A. Weller, M. Herzum, Immunopathogenic Mechanisms in Experimental Myocarditis: Evidence for Autoimmunity to the Virus Receptor and Antigenic Mimicry between the Virus and Cardiocyte Springer, Berlin, Heidelberg. pp. 179- 187 ,(1988) , 10.1007/978-3-642-73610-0_17
Woodruff Jf, Viral myocarditis. A review. American Journal of Pathology. ,vol. 101, pp. 425- 484 ,(1980)
S A Huber, M Estrin, Coxsackievirus B3-induced myocarditis. Autoimmunity is L3T4+ T helper cell and IL-2 independent in BALB/c mice. American Journal of Pathology. ,vol. 127, pp. 335- 341 ,(1987)
J. Olszewski, S. A. Huber, P. A. Lodge, M. Herzum, Coxsackievirus B-3 myocarditis. Acute and chronic forms of the disease caused by different immunopathogenic mechanisms. American Journal of Pathology. ,vol. 128, pp. 455- 463 ,(1987)
C.J. Gauntt, E.K. Godeny, In situ immune autoradiographic identification of cells in heart tissues of mice with coxsackievirus B3-induced myocarditis. American Journal of Pathology. ,vol. 129, pp. 267- 276 ,(1987)
C. C. Marboe, D. M. Knowles, M. B. Weiss, P. C. Ursell, J. J. Fenoglio, Characterization of the Inflammatory Infiltrate in Human Myocarditis — An Endomyocardial Biopsy Study Springer, Berlin, Heidelberg. pp. 74- 82 ,(1984) , 10.1007/978-3-642-95448-1_9
E K Godeny, C J Gauntt, Involvement of natural killer cells in coxsackievirus B3-induced murine myocarditis. Journal of Immunology. ,vol. 137, pp. 1695- 1702 ,(1986)
C W Lutton, C J Gauntt, Coxsackievirus B3 infection alters plasma membrane of neonatal skin fibroblasts. Journal of Virology. ,vol. 60, pp. 294- 296 ,(1986) , 10.1128/JVI.60.1.294-296.1986
Judith J. Woodruff, Jack F. Woodruff, Involvement of T Lymphocytes in the Pathogenesis of Coxsackie Virus B3 Heart Disease Journal of Immunology. ,vol. 113, pp. 1726- 1734 ,(1974)