Proteomic approaches for studying chemoresistance in cancer.

摘要: The role of various proteins involved in drug resistance tumor cells is discussed this review. Two types studies are covered: those performed the preproteomics era and carried out with modern proteomic tools, namely 2D (electrophoretic) maps chromatography. In preproteomic studies, one protein had generally been held responsible for a given chemoresistance. However, analysis via tools may reveal entire sets that up- or downregulated (or switched on/off) chemoresistant cell lines compared parental lines. Therefore, it appears more realistic to expect exposure drugs results activation different mechanisms resistance. Such investigations have led broadly shared opinion resistance, specific drug-resistant phenotype consists several molecular simultaneously active. pape...