Myelin breakdown and basic protein
作者： M. Röyttä , H. Frey , P.J. Riekkinen , H. Laaksonen , U.K. Rinne
DOI: 10.1016/0014-4886(74)90109-5
关键词:
摘要: Abstract The purpose of the present work was to study mechanisms myelin breakdown in experimental conditions and fate protein components myelin, especially that basic which is known be important demyelinative disorders. results showed when incubated alone without any added enzymes there a dissociation from acidic but at neutral pH no change protein. Whereas presence acid proteinase-containing fraction profuse changes were also noted proteolipid When separated isolated brain it seen did not result fractions. trypsin-containing complete loss after 2 hr. These suggest influence proteinase quite different trypsin. This supports theory BP mediated through proteinases, while action seems very slow, almost nonexistent.
elsevier.com
sci-hub.se 参考文章(43)
L P Chao, E R Einstein, Isolation and characterization of an active fragment from enzymatic degradation of encephalitogenic protein. Journal of Biological Chemistry. ,vol. 243, pp. 6050- 6055 ,(1968) , 10.1016/S0021-9258(18)94525-4
J. J. Bubis, M. Wolman, Study of the localization of the encephalomyelitis-producing protien in the myelin sheath. Acta Neuropathologica. ,vol. 10, pp. 356- 358 ,(1968) , 10.1007/BF00690710
P.J. Riekkinen, U.K. Rinne, A.U. Arstila, T. Kurihara, T.T. Pelliniemi, Studies on the pathogenesis of multiple sclerosis. 2',3'-Cyclic nucleotide 3-phosphohydrolase as marker of demyelination and correlation of findings with lysosomal changes. Journal of the Neurological Sciences. ,vol. 15, pp. 113- 120 ,(1972) , 10.1016/0022-510X(72)90124-4
Li-Pen Chao, Elizabeth Roboz Einstein, Localization of the Active Site through Chemical Modification of the Encephalitogenic Protein Journal of Biological Chemistry. ,vol. 245, pp. 6397- 6403 ,(1970) , 10.1016/S0021-9258(18)62623-7
P. J. Riekkinen, J. Palo, A. U. Arstila, H. J. Savolainen, U. K. Rinne, E. K. Kivalo, H. Frey, Protein Composition of Multiple Sclerosis Myelin JAMA Neurology. ,vol. 24, pp. 545- 549 ,(1971) , 10.1001/ARCHNEUR.1971.00480360079010
R. E. Martenson, Gladys E. Deibler, Marian W. Kies, ELECTROPHORETIC CHARACTERIZATION OF BASIC PROTEINS IN ACID EXTRACTS OF CENTRAL NERVOUS SYSTEM TISSUE Journal of Neurochemistry. ,vol. 18, pp. 2417- 2426 ,(1971) , 10.1111/J.1471-4159.1971.TB00197.X
Elizabeth Roboz Einstein, Kanu B. Dalal, Judit Csejtey, Biochemical maturation of the central nervous system. II. Protein and proteolytic enzyme changes Brain Research. ,vol. 18, pp. 35- 49 ,(1970) , 10.1016/0006-8993(70)90455-5
M.G. Rumsby, P.J. Riekkinen, A.V. Arstila, A critical evaluation of myelin purification. Non-specific esterase activity associated with central nerve myelin preparations Brain Research. ,vol. 24, pp. 495- 516 ,(1970) , 10.1016/0006-8993(70)90188-5
P. J. Riekkinen, U. K. Rinne, A. U. Arstila, Neurochemical and morphological studies on demyelination in multiple sclerosis with special reference to etiological aspects. Zeitschrift f�r Neurologie. ,vol. 203, pp. 91- 104 ,(1972) , 10.1007/BF00316038
J. F. Hallpike, C. W. M. Adams, O. B. Bayliss, Histochemistry of myelin. IX. Neutral and acid proteinases in early Wallerian degeneration. Histochemical Journal. ,vol. 2, pp. 209- 218 ,(1970) , 10.1007/BF01003470