ALK-positive non-small cell lung cancer: mechanisms of resistance and emerging treatment options.

作者: Conor E. Steuer , Suresh S. Ramalingam

DOI: 10.1002/CNCR.28597

关键词:

摘要: … EGFR-mutated lung cancers develop TKI resistance in approximately the same time intervals as ALK-rearranged lung cancers. In approximately 50% of patients, EGFR TKI resistance …

参考文章(47)
Sven Perner, Patrick L Wagner, Francesca Demichelis, Rohit Mehra, Christopher J LaFargue, Benjamin J Moss, Stefanie Arbogast, Alex Soltermann, Walter Weder, Thomas J Giordano, David G Beer, David S Rickman, Arul M Chinnaiyan, Holger Moch, Mark A Rubin, EML4-ALK Fusion Lung Cancer: A Rare Acquired Event Neoplasia. ,vol. 10, pp. 298- 302 ,(2008) , 10.1593/NEO.07878
Andrew J. Weickhardt, Robert C. Doebele, W. Thomas Purcell, Paul A. Bunn, Ana B. Oton, Micol S. Rothman, Margaret E. Wierman, Tony Mok, Sanjay Popat, Julie Bauman, Jorge Nieva, Silvia Novello, Sai-Hong Ignatius Ou, D. Ross Camidge, Symptomatic reduction in free testosterone levels secondary to crizotinib use in male cancer patients Cancer. ,vol. 119, pp. 2383- 2390 ,(2013) , 10.1002/CNCR.28089
Soyeon Kim, Tae Min Kim, Dong-Wan Kim, Heounjeong Go, Bhumsuk Keam, Se-Hoon Lee, Ja-Lok Ku, Doo Hyun Chung, Dae Seog Heo, None, Heterogeneity of Genetic Changes Associated with Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancer Journal of Thoracic Oncology. ,vol. 8, pp. 415- 422 ,(2013) , 10.1097/JTO.0B013E318283DCC0
Hideki Kimura, Takahiro Nakajima, Kengo Takeuchi, Manabu Soda, Hiroyuki Mano, Toshihiko Iizasa, Yukiko Matsui, Mitsuru Yoshino, Masato Shingyoji, Meiji Itakura, Makiko Itami, Dai Ikebe, Sana Yokoi, Hajime Kageyama, Miki Ohira, Akira Nakagawara, ALK fusion gene positive lung cancer and 3 cases treated with an inhibitor for ALK kinase activity. Lung Cancer. ,vol. 75, pp. 66- 72 ,(2012) , 10.1016/J.LUNGCAN.2011.05.027
Young Lim Choi, Manabu Soda, Yoshihiro Yamashita, Toshihide Ueno, Junpei Takashima, Takahiro Nakajima, Yasushi Yatabe, Kengo Takeuchi, Toru Hamada, Hidenori Haruta, Yuichi Ishikawa, Hideki Kimura, Tetsuya Mitsudomi, Yoshiro Tanio, Hiroyuki Mano, EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors The New England Journal of Medicine. ,vol. 363, pp. 1734- 1739 ,(2010) , 10.1056/NEJMOA1007478
Youngil Koh, Dong-Wan Kim, Tae Min Kim, Se-Hoon Lee, Yoon Kyung Jeon, Doo Hyun Chung, Young-Whan Kim, Dae Seog Heo, Woo-Ho Kim, Yung-Jue Bang, None, Clinicopathologic characteristics and outcomes of patients with anaplastic lymphoma kinase-positive advanced pulmonary adenocarcinoma: suggestion for an effective screening strategy for these tumors. Journal of Thoracic Oncology. ,vol. 6, pp. 905- 912 ,(2011) , 10.1097/JTO.0B013E3182111461
Len Neckers, Hsp90 inhibitors as novel cancer chemotherapeutic agents Trends in Molecular Medicine. ,vol. 8, pp. S55- S61 ,(2002) , 10.1016/S1471-4914(02)02316-X
Johannes M. Heuckmann, Michael Hölzel, Martin L. Sos, Stefanie Heynck, Hyatt Balke-Want, Mirjam Koker, Martin Peifer, Jonathan Weiss, Christine M. Lovly, Christian Grütter, Daniel Rauh, William Pao, Roman K. Thomas, ALK Mutations Conferring Differential Resistance to Structurally Diverse ALK Inhibitors Clinical Cancer Research. ,vol. 17, pp. 7394- 7401 ,(2011) , 10.1158/1078-0432.CCR-11-1648
Hui-Yong Sun, Feng-Qin Ji, A molecular dynamics investigation on the crizotinib resistance mechanism of C1156Y mutation in ALK. Biochemical and Biophysical Research Communications. ,vol. 423, pp. 319- 324 ,(2012) , 10.1016/J.BBRC.2012.05.120
Kenichi Suda, Ryoichi Onozato, Yasushi Yatabe, Tetsuya Mitsudomi, EGFR T790M Mutation: A Double Role in Lung Cancer Cell Survival? Journal of Thoracic Oncology. ,vol. 4, pp. 1- 4 ,(2009) , 10.1097/JTO.0B013E3181913C9F