EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors
作者： Young Lim Choi , Manabu Soda , Yoshihiro Yamashita , Toshihide Ueno , Junpei Takashima
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摘要: The EML4 (echinoderm microtubule-associated protein-like 4)-ALK (anaplastic lymphoma kinase) fusion-type tyrosine kinase is an oncoprotein found in 4 to 5% of non-small-cell lung cancers, and clinical trials specific inhibitors ALK for the treatment such tumors are currently under way. Here, we report discovery two secondary mutations within domain EML4-ALK tumor cells isolated from a patient during relapse phase with inhibitor. Each mutation developed independently subclones conferred marked resistance different inhibitors. (Funded by Ministry Health, Labor, Welfare Japan, others.).
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