Trade-offs between effectiveness and cost in bifunctional enzyme circuit with concentration robustness.

摘要: A fundamental trade-off in biological systems is whether they consume resources to perform functions or save resources. Bacteria need reliably and rapidly respond input signals by using limited cellular However, excessive resource consumption will become a burden for bacteria growth. To investigate the relationship between functional effectiveness cost, we study ubiquitous bifunctional enzyme circuit, which robust fluctuations protein concentration responds quickly signal changes. We show that relationships exist cost. Expressing more proteins of circuit increases robustness response speed but affects bacterial In particular, our reveals general free-energy dissipation rate, speed, robustness. The free energy plays an important role speed. High can only be achieved with large amount addition, noise output increasing while time decreases also calculate EnvZ-OmpR system nitrogen assimilation system, both have enzyme. Similar results indicate these are mainly derived from specific feature circuits not relevant details models. According relationships, take compromise solution performs at reasonable