Src: c-Src protein-tyrosine kinase (vertebrates)
作者： Hidesaburo Hanafusa
DOI: 10.1016/B978-012324719-3/50139-4
关键词:
摘要: The viral SRC [v-SRC] gene was identified as the oncogene of Rous sarcoma virus. c-SRC genes in chicken, human, and mouse genomes were cloned homologues v-SRC. function c-Src normal cells is not known. In domain structure, N-terminus myristoylated. Immediately after translation, M1 removed G2 region from residues 10 to 80 most variable among Src family proteins considered contribute their biological specificities. Two regions known homology 3 2 (SH3/SH2) are located centrally. Related found numerous other proteins, they play roles interaction with cellular proteins. primarily localized at cytoplasmic face plasma membrane, but a significant fraction detectable perinuclear region, which may correspond association endosomes. Some v-Src present focal adhesions cell–cell contact. Myristoylation required for membranes. It expressed all low levels, higher expression can be seen neural tissues, platelets, macrophages.
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