Interferon-β modulates protein synthesis in the central nervous system
作者： Susanne Beyer , Gergana Raether , Konstantin Stadler , Raimund Hoffrogge , Christian Scharf
DOI: 10.1016/J.JNEUROIM.2009.06.004
关键词:
摘要: Interferon-beta (IFN-beta), acting canonically via the modulation of transcription, affects neocortical pyramidal neurons. By use 2-D differential gel electrophoresis and subsequent mass spectrometry we identified IFN-beta regulated proteins in central nervous system. These are involved cytoskeleton assembly, protein transport nucleotide metabolism and, as such, serve regenerative protective functions. Electrophysiologically, mediated synthesis is essential for part excitatory neuronal effects, revealed under blockade biosynthesis. This study presents novel effects system begins to unravel mechanism behind known excitability changes
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Christine R. Rozanas, Stacey M. Loyland, Capabilities Using 2-D DIGE in Proteomics Research Methods in Molecular Biology. ,vol. 441, pp. 1- 18 ,(2008) , 10.1007/978-1-60327-047-2_1
Mee-Ohk Kim, Qiusheng Si, Jian Nian Zhou, Richard G. Pestell, Celia F. Brosnan, Joseph Locker, Sunhee C. Lee, Interferon‐β activates multiple signaling cascades in primary human microglia Journal of Neurochemistry. ,vol. 81, pp. 1361- 1371 ,(2002) , 10.1046/J.1471-4159.2002.00949.X
Ronald K. H. Liem, Gee Y. Ching, Analysis of the roles of the head domains of type IV rat neuronal intermediate filament proteins in filament assembly using domain-swapped chimeric proteins Journal of Cell Science. ,vol. 112, pp. 2233- 2240 ,(1999)
Stefan Stamm, Diana Casper, Jonathan Dinsmore, Charles A. Kaufmann, Jürgen Brosius, David M. Helfman, Clathrin light chain B: gene structure and neuron-specific splicing Nucleic Acids Research. ,vol. 20, pp. 5097- 5103 ,(1992) , 10.1093/NAR/20.19.5097
Tadatsugu Taniguchi, Akinori Takaoka, A weak signal for strong responses: interferon-alpha/beta revisited. Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 378- 386 ,(2001) , 10.1038/35073080
H. L. Ennis, M. Lubin, CYCLOHEXIMIDE: ASPECTS OF INHIBITION OF PROTEIN SYNTHESIS IN MAMMALIAN CELLS. Science. ,vol. 146, pp. 1474- 1476 ,(1964) , 10.1126/SCIENCE.146.3650.1474
Laddawan Karachot, Yoshinori Shirai, Réjan Vigot, Tetsuo Yamamori, Masao Ito, Rapidly turned over protein maintains metabotropic synaptic transmission in Purkinje cells. Neuroreport. ,vol. 11, pp. 2903- 2906 ,(2000) , 10.1097/00001756-200009110-00015
Olga Barca, Susana Ferré, Marcos Seoane, José M Prieto, Manuela Lema, Rosa Señarı́s, Vı́ctor M Arce, Interferon beta promotes survival in primary astrocytes through phosphatidylinositol 3-kinase. Journal of Neuroimmunology. ,vol. 139, pp. 155- 159 ,(2003) , 10.1016/S0165-5728(03)00160-7
Shahab Uddin, Beata Majchrzak, Joanna Woodson, Pony Arunkumar, Yazan Alsayed, Richard Pine, Peter R. Young, Eleanor N. Fish, Leonidas C. Platanias, Activation of the p38 Mitogen-activated Protein Kinase by Type I Interferons Journal of Biological Chemistry. ,vol. 274, pp. 30127- 30131 ,(1999) , 10.1074/JBC.274.42.30127
Shahab Uddin, Beata Majchrzak, Pu-Chen Wang, Sanjiv Modi, Mohammad K. Khan, Eleanor N. Fish, Leonidas C. Platanias, Interferon-Dependent Activation of the Serine Kinase PI 3′-Kinase Requires Engagement of the IRS Pathway but Not the Stat Pathway Biochemical and Biophysical Research Communications. ,vol. 270, pp. 158- 162 ,(2000) , 10.1006/BBRC.2000.2402