The Skin-Resident Immune Network

摘要: The skin provides an effective physical and biological barrier against environmental pathogenic insults whilst ensuring tolerance commensal microbes. This protection is afforded by the unique anatomy cellular composition of skin, particularly vast network skin-associated immune cells. These include long-appreciated tissue-resident macrophages, dendritic cells, mast as well more recently described dermal γδ T cells innate lymphoid Collectively, these orchestrate defense a wide range pathogens challenges, but also perform number homeostatic functions. Here, we review recent developments in our understanding various roles that leukocyte subsets play cutaneous immunobiology, introduce newer members system. Implications for human disease are discussed.