Local Targeted Therapy of Liver Metastasis from Colon Cancer by Galactosylated Liposome Encapsulated with Doxorubicin

摘要: Since regional drug administration enables to maintain a high concentration within tumors, we compared the plasma and biodistribution of doxorubicin (Dox) from drug-loaded conventional liposomes by local or systemic administration. The results demonstrated that was substantially improved in liver as well decrease blood other organs spleen injection mimicking portal vein perfusion (regional administration). To further investigate targeted therapeutic effect galactosylated liposome encapsulated administration, targeting were prepared incorporating galactosylated-DPPE liposomes. Liposome uptake verified vitro vivo fluorescence microscopy xenogen IVIS imaging system, respectively. showed galactose presented stronger specific cell human hepatocellular carcinoma HepG2 cells non-targeted In intra-hepatic deposition via more than tail had higher fluorescent intensity over post anti-tumor various routes for both liposomal formulations evaluated using murine metastasis model colon cancer. indicated tumor progression mesenteric lymph nodes significantly suppressed Dox-loaded injection, while no significance observed formulations. Our data great promise treatment