Phase II study of combined administration of 5-fluorouracil, epirubicin and mitomycin-C by hepatic artery infusion in patients with liver metastases of gastric cancer.
作者： Takashi Kumada , Yasuaki Arai , Kazuki Itoh , Yukio Takayasu , Kenji Nakamura
DOI: 10.1159/000012034
关键词:
摘要: This multicenter phase II study evaluated the efficacy of FEM regimen (5-fluorouracil 333 mg/m2 each week, epirubicin 30 once every 4 weeks and mitomycin-C 2.7 2 weeks) administered by hepatic artery infusion (HAI) for unresectable metastases gastric cancer. The response rates were 55.6% (complete response: 3, partial 32, no change: 21, progressive disease: 7/63) mean 50% survival was 10.5 months. Most responders died due to progression extrahepatic lesions. HAI induced a high rate in patients with cancer, prognosis-determining factor existence lesions many patients.
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