The separate and combined effects of MHC genotype, parasite clone, and host gender on the course of malaria in mice

摘要: The link between host MHC (major histocompatibility complex) genotype and malaria is largely based on correlative data with little or no experimental control of potential confounding factors. We used an mouse model to test for main effects MHC-haplotypes, heterozygosity, × parasite clone interactions. experimentally infected MHC-congenic mice (F2 segregants, homo- heterozygotes, males females) one two clones Plasmodium chabaudi recorded disease progression. found that haplotype each have a significant influence the course disease, but there was by interaction. evidence overdominance nor any other sort heterozygote advantage disadvantage. When tested under conditions, variation in can significantly malaria. However, through dominance resistance cannot be assumed case single-strain infections. Future studies might focus interaction heterozygosity multiple-clone