Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation.

摘要: Induction of K(Ca)3.1 (IKCa) potassium channel plays an important role in vascular smooth muscle cell proliferation. Here, we report that the gene encoding (KCNN4) contains a functional repressor element 1-silencing transcription factor (REST or NRSF) binding site and is repressed by REST. Although not previously associated with cells, REST present recruited to KCNN4 situ. Significantly, expression declines when there cellular proliferation, showing inverse relationship K(Ca)3.1. Downregulated upregulated are also evident cells human neointimal hyperplasia grown organ culture. Furthermore, inhibition suppresses formation, exogenous reduces impact show unrecognized as switch regulating consequently phenotype disease.