Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission
作者： Richard A Cone , Timothy Hoen , XiXi Wong , Raed Abusuwwa , Deborah J Anderson
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摘要: Background Microbicides must protect against STD pathogens without causing unacceptable toxic effects. Microbicides based on nonoxynol-9 (N9) and other detergents disrupt sperm, HSV HIV membranes, these agents are effective contraceptives. But paradoxically N9 fails to women pathogens, most likely because it causes effects that increase susceptibility. The mouse HSV-2 vaginal transmission model reported here: (a) Directly tests for susceptibility HSV-2, (b) Determines in vivo whether a microbicide can toxicities susceptibility, (c) Identifies those best correlate with the increased
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