Wnt Signaling: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma
作者： Zeeshan Javed , Hafiz Muhammad Farooq , Mukhtar Ullah , Muhammad Zaheer Iqbal , Qamar Raza
DOI: 10.31557/APJCP.2019.20.4.995
关键词:
摘要: Cellular maintenance and development are two fundamental mechanisms regulated by the canonical Wnt signaling pathway. Wnt/beta-catenin pathway controls a myriad of cellular processes that essential for normal cell functioning. Cell cycle progression, differentiation, fate determination, migration generally orchestrated signaling. Altered has been considered promoting event different types cancers oncogenic potential have discussed in many cancer types, including breast, colon, pancreatic as well head neck. Furthermore, is critical stemness both stem cells. This review sheds new light on explains how it can regulate physiological curtail cancer. It depicts vital functions growth differentiation focusing current druggable targets ascribed recent studies. Thus, retains tremendous eradicating neck squamous carcinoma.
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