Apigenin role as cell-signaling pathways modulator: implications in cancer prevention and treatment.
作者： Monica Butnariu , Zeeshan Javed , Javad Sharifi-Rad , Shahid Raza , Muhammad Javed Iqbal
DOI: 10.1186/S12935-021-01888-X
关键词:
摘要: Cancer is a complex disease orchestrated by various extrinsic and intrinsic pathways. In recent years, there has been keen interest towards the development of natural extracts-based cancer therapeutics with minimum adverse effects. pursuit effective strategy, wide variety products-derived compounds have addressed for their anticancer Apigenin naturally-occurring flavonoid present abundantly in fruits vegetables. Decades research delineated pharmacological biological properties apigenin. Specifically, apigenin-mediated activities documented types cancer, but generalized scientific evidence encompassing molecular interactions processes, such as regulation apoptotic machinery, aberrant cell signaling oncogenic protein network not comprehensively covered. this sense, review we attempted to focus on pathways cancers. We also cutting-edge which unveiled remarkable abilities apigenin interact microRNAs modulate key cellular special emphasis nano-formulations that can help targeted delivery be therapeutic solution treatment
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