Exploring the various aspects of the pathological role of vascular endothelial growth factor (VEGF) in diabetic retinopathy

摘要: Diabetic retinopathy, a sight-threatening microvascular complication of diabetes mellitus, is initiated by retinal endothelial dysfunction and succeeded various pathological events, eventually resulting in vision-loss. These events are regulated numerous mediators, including vascular growth factor (VEGF), which induces the progression characterizing diabetic such as neovascularization macular edema. VEGF physiologically required for regulating proliferation assembling cells, during vasculogenesis, well their maintenance survival throughout lifetime blood vessels. However, conditions induced body (such ischemia, oxidative stress overactivation protein kinase C), upregulate expression VEGF, thereby deviating it from its physiological role leading to demonstrations angiogenesis, increased permeability endothelium, decreased inhibition pro-apoptotic proteins activation other inflammatory mediators. Such disrupt homeostasis play key roles pathophysiology retinopathy. Hence, acknowledging VEGF-mediated pathways helps understanding deeper aspects related this disorder. Targeting inhibiting disease might provide an effective alternative therapy hence prove beneficial treatment