Noninvasive Monitoring of Therapy-Induced Microvascular Changes in a Pancreatic Cancer Model Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging with P846, a New Low-Diffusible Gadolinium-Based Contrast Agent
作者： Veerle F. Casneuf , Louke Delrue , Nancy Van Damme , Pieter Demetter , Philippe Robert
DOI: 10.1667/RR2068.1
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摘要: Abstract A predictive technique in the management of patients with cancer could improve therapeutic index by allowing better individualization treatment. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a noninvasive that can provide anatomical and physiological information on tumor its microenvironment. We studied effect chemotherapy (gemcitabine), anti-angiogenesis therapy (sunitinib) radiotherapy kinetics DCE-MRI parameters preclinical model pancreatic using P846, new low-diffusible contrast agent. Mice underwent before treatment (MRI1), after 1 week (MRI2), 1 additional week (MRI3). Combined sunitinib had synergistic growth. In radiotherapy/sunitinib-treated mice, decrease Ktrans at MRI2 predicted superior antivascular antitumor an early time. An increased MRI2, as seen gemcitabine- gemcitabine/sunitinib...
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