Physicochemical characterization and stability of microbeads containing cod-liver oil encircled with natural cyclodextrins

摘要: The ability of cyclodextrins (CDs) to solubilize cod-liver oil in aqueous solutions was evaluated. Only the natural α-cyclodextrin (αCD) and γ-cyclodextrin (γCD) were able fully disperse 10 % (v/v) solutions. Confocal imaging revealed that located center CD enveloped microbeads (<20 μm diameter) where it enclosed within nanocompartments (<1 diameter). microbead suspensions lyophilized produce dry powder with rough surfaces. To assess stability oil/γCD (3:1 molar ratio) powder, three groups samples incubated over a period 1, 2, 4, 12 84 weeks. Group 1 (G1) group 2 (G2) at 25 °C 60 humidity. G1 exposed O2 for min before sealing off glass containers while G2 kept under nitrogen. 3 stored accelerated conditions 40 75 humidity reference pure oil. Results indicated encapsulating γCD delays oxidative degradation when oxygen is present, but does not significantly decrease or increase long term anaerobic conditions. Cod-liver could be compressed into tablets without decreasing integrity encapsulation. might interest pharmaceutical industry as carrier lipophilic drugs.