Present indications for adjuvant therapy in resectable rectal cancer.

作者: Bruce Minsky

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摘要: Combined modality therapy is an effective adjuvant for many patients with clinically resectable rectal cancer. The indications cancer are based on the pattern of failure after surgery. Despite radical surgery, local-regional frequently occurs in transmural or node-positive cancers. incidence treatment pelvis directly correlated extent penetration (microscopic vs gross) and additional risk lymph node metastases. In post-operative setting its use dictated by pathologic stage type operation (i.e. conventional surgery a local excision). choice which regimen to recommend non-protocol remains controversial. If 5-FU alone used, then it best administered continuous infusion. preoperative setting, depends clinical need sphincter preservation. Phase I/II trials examining newer chemotherapeutic agents such as Tomudex, UFT/leucovorin, CPT-11, oxaliplatin, eniluracil capecitabine radiation progress. This review examines both selection criteria results combined

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