Gender-related metabolomics and lipidomics: From experimental animal models to clinical evidence.
作者： Matteo Audano , Mariateresa Maldini , Emma De Fabiani , Nico Mitro , Donatella Caruso
DOI: 10.1016/J.JPROT.2017.11.001
关键词:
摘要: Abstract Lipidomics and metabolomics have emerged as important tools for the characterization of specific physiological pathological traits. The selection analytical approaches choice a targeted rather than an untargeted strategy in find their reasons driving hypothesis study, sample features instrumental availability. Moreover, last years, − omics found application study sex-related dimorphism. In this review, lipidomic metabolomic analyses are presented biomedical perspective. Here, we provide updated overview covering recent applications lipidomics area differences human preclinical models. Experimental evidence underlines that sex is one most relevant biological variables significantly influencing profiles. This knowledge can be exploited identification novel sex-specific biomarkers innovative targets gender medicine.
sci-hub.se 参考文章(99)
Huan Cai, Wei-na Cong, Sunggoan Ji, Sarah Rothman, Stuart Maudsley, Bronwen Martin, Metabolic Dysfunction in Alzheimer’s Disease and Related Neurodegenerative Disorders Current Alzheimer Research. ,vol. 9, pp. 5- 17 ,(2012) , 10.2174/156720512799015064
Aihua Zhang, Hui Sun, Xijun Wang, Recent highlights of metabolomics for traditional Chinese medicine. Die Pharmazie. ,vol. 67, pp. 667- ,(2012)
Masataka Wakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Capillary electrophoresis-mass spectrometry Methods of Molecular Biology. ,vol. 1277, pp. 113- 122 ,(2015) , 10.1007/978-1-4939-2377-9_9
Paulo Henrique Gonçalves Dias Diniz, Mayara Ferreira Barbosa, Karla Danielle Tavares de Melo Milanez, Marcelo Fabián Pistonesi, Mário César Ugulino de Araújo, Using UV–Vis spectroscopy for simultaneous geographical and varietal classification of tea infusions simulating a home-made tea cup Food Chemistry. ,vol. 192, pp. 374- 379 ,(2016) , 10.1016/J.FOODCHEM.2015.07.022
Marielle S. Köberlin, Berend Snijder, Leonhard X. Heinz, Christoph L. Baumann, Astrid Fauster, Gregory I. Vladimer, Anne-Claude Gavin, Giulio Superti-Furga, A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses Cell. ,vol. 162, pp. 170- 183 ,(2015) , 10.1016/J.CELL.2015.05.051
Raúl González-Domínguez, Tamara García-Barrera, Javier Vitorica, José Luis Gómez-Ariza, Metabolomic investigation of systemic manifestations associated with Alzheimer's disease in the APP/PS1 transgenic mouse model Molecular BioSystems. ,vol. 11, pp. 2429- 2440 ,(2015) , 10.1039/C4MB00747F
Dirk K. Wissenbach, Markus R. Meyer, Armin A. Weber, Daniela Remane, Andreas H. Ewald, Frank T. Peters, Hans H. Maurer, Towards a universal LC–MS screening procedure – can an LIT LC–MSn screening approach and reference library be used on a quadrupole‐LIT hybrid instrument? Journal of Mass Spectrometry. ,vol. 47, pp. 66- 71 ,(2012) , 10.1002/JMS.2027
Jan Krumsiek, Kirstin Mittelstrass, Kieu Trinh Do, Ferdinand Stückler, Janina Ried, Jerzy Adamski, Annette Peters, Thomas Illig, Florian Kronenberg, Nele Friedrich, Matthias Nauck, Maik Pietzner, Dennis O. Mook-Kanamori, Karsten Suhre, Christian Gieger, Harald Grallert, Fabian J. Theis, Gabi Kastenmüller, Gender-specific pathway differences in the human serum metabolome Metabolomics. ,vol. 11, pp. 1815- 1833 ,(2015) , 10.1007/S11306-015-0829-0
Laura K. Teune, Remco J. Renken, Bauke M. de Jong, Antoon T. Willemsen, Matthias J. van Osch, Jos B.T.M. Roerdink, Rudi A. Dierckx, Klaus L. Leenders, Parkinson's disease-related perfusion and glucose metabolic brain patterns identified with PCASL-MRI and FDG-PET imaging. NeuroImage: Clinical. ,vol. 5, pp. 240- 244 ,(2014) , 10.1016/J.NICL.2014.06.007
Jianguo Xia, Igor V. Sinelnikov, Beomsoo Han, David S. Wishart, MetaboAnalyst 3.0—making metabolomics more meaningful Nucleic Acids Research. ,vol. 43, ,(2015) , 10.1093/NAR/GKV380