Alternariol disturbs oocyte maturation and preimplantation development
作者： Eric J. Schoevers , Regiane R. Santos , Bernard A. J. Roelen
DOI: 10.1007/S12550-019-00372-W
关键词:
摘要: Alternariol (AOH) is produced by fungi of the genus Alternaria and can be found in fruits, vegetables, grains. Besides oestrogenic activity demonstrated vitro, this mycotoxin causes DNA damage cell cycle arrest. Based on this, effect AOH was investigated porcine female gametes during vitro maturation subsequent initial embryo development. A first experiment assessed a dose-response (5, 10, or 20 μmol/l) cumulus expansion oocyte nuclear maturation, presence absence follicular fluid (FF). second evaluated exposure development, both periods, preimplantation Although FF protected oocytes from deleterious AOH, it did not avoid decrease cells (5 μmol/l regardless FF). Moreover, to resulted degeneration (10 μmol/l FF) occurrence aberrations mature 20 μmol/l Exposure 5 μmol/l sufficient impair
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