Characterization and expression analysis of gene encoding heme peroxidase HPX15 in major Indian malaria vector Anopheles stephensi (Diptera: Culicidae).
作者： Mithilesh Kajla , Parik Kakani , Tania Pal Choudhury , Kuldeep Gupta , Lalita Gupta
DOI: 10.1016/J.ACTATROPICA.2016.02.028
关键词:
摘要: The interaction of mosquito immune system with Plasmodium is critical in determining the vector competence. Thus, blocking crucial molecules that regulate parasite development might be effective controlling disease transmission. In this study, we characterized a full-length AsHPX15 gene from major Indian malaria Anopheles stephensi. This true ortholog gambiae heme peroxidase AgHPX15 (AGAP013327), which modulates midgut immunity and regulates falciparum development. We found highly induced developmental stages blood fed midguts. addition, lineage-specific has identical features 65–99% amino acids identity other HPX15 genes present eighteen worldwide-distributed anophelines. discuss conserved serve as common target to manipulate arresting inside host.
sci-hub.se 参考文章(45)
Kazutaka Akagi, Hitoshi Ueda, Regulatory mechanisms of ecdysone-inducible Blimp-1 encoding a transcriptional repressor that is important for the prepupal development in Drosophila. Development Growth & Differentiation. ,vol. 53, pp. 697- 703 ,(2011) , 10.1111/J.1440-169X.2011.01276.X
S J Bray, F C Kafatos, Developmental function of Elf-1: an essential transcription factor during embryogenesis in Drosophila. Genes & Development. ,vol. 5, pp. 1672- 1683 ,(1991) , 10.1101/GAD.5.9.1672
Anthony Mathelier, Xiaobei Zhao, Allen W. Zhang, François Parcy, Rebecca Worsley-Hunt, David J. Arenillas, Sorana Buchman, Chih-yu Chen, Alice Chou, Hans Ienasescu, Jonathan Lim, Casper Shyr, Ge Tan, Michelle Zhou, Boris Lenhard, Albin Sandelin, Wyeth W. Wasserman, JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles. Nucleic Acids Research. ,vol. 42, pp. 142- 147 ,(2014) , 10.1093/NAR/GKT997
Malou Fraiture, Richard H.G. Baxter, Stefanie Steinert, Yogarany Chelliah, Cécile Frolet, Wilber Quispe-Tintaya, Jules A. Hoffmann, Stéphanie A. Blandin, Elena A. Levashina, Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium. Cell Host & Microbe. ,vol. 5, pp. 273- 284 ,(2009) , 10.1016/J.CHOM.2009.01.005
M. Narasimha, A. Uv, A. Krejci, N. H. Brown, S. J. Bray, Grainy head promotes expression of septate junction proteins and influences epithelial morphogenesis. Journal of Cell Science. ,vol. 121, pp. 747- 752 ,(2008) , 10.1242/JCS.019422
M. Shahabuddin, S. Cociancich, H. Zieler, The Search for Novel Malaria Transmission-blocking Targets in the Mosquito Midgut. Parasitology Today. ,vol. 14, pp. 493- 497 ,(1998) , 10.1016/S0169-4758(98)01348-9
G. Dimopoulos, G. K. Christophides, S. Meister, J. Schultz, K. P. White, C. Barillas-Mury, F. C. Kafatos, Genome expression analysis of Anopheles gambiae: Responses to injury, bacterial challenge, and malaria infection Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 8814- 8819 ,(2002) , 10.1073/PNAS.092274999
Sonam Vijay, Manmeet Rawat, Tridibes Adak, Rajnikant Dixit, Nutan Nanda, Harish Srivastava, Joginder K Sharma, Godavarthi BKS Prasad, Arun Sharma, None, Parasite killing in malaria non-vector mosquito Anopheles culicifacies species B: implication of nitric oxide synthase upregulation. PLOS ONE. ,vol. 6, ,(2011) , 10.1371/JOURNAL.PONE.0018400
Lalita Gupta, Alvaro Molina-Cruz, Sanjeev Kumar, Janneth Rodrigues, Rajnikant Dixit, Rodolfo E. Zamora, Carolina Barillas-Mury, The STAT Pathway Mediates Late-Phase Immunity against Plasmodium in the Mosquito Anopheles gambiae Cell Host & Microbe. ,vol. 5, pp. 498- 507 ,(2009) , 10.1016/J.CHOM.2009.04.003
Zalán Péterfi, Miklós Geiszt, Peroxidasins: novel players in tissue genesis Trends in Biochemical Sciences. ,vol. 39, pp. 305- 307 ,(2014) , 10.1016/J.TIBS.2014.05.005